Root and tuber crops, such as cassava and sweet potatoes, play a critical role in global food and nutrition security, particularly in sub-Saharan Africa, where they serve as staple foods and income sources. However, these crops are highly perishable and face significant post-harvest challenges, including physiological deterioration, nutrient loss, and limited value-added options. Addressing these challenges is essential to achieving sustainable agricultural systems and resilient food supply chains.This presentation explores innovative strategies for enhancing the postharvest quality, utilization, and marketability of cassava and sweet potato through integrated approaches. Emphasis will be placed on value-added technologies such as functional food product development, biofortification, and the use of probiotics and natural antioxidants to extend shelf life and improve nutritional outcomes. Furthermore, the role of digital agriculture tools, including Near-Infrared Spectroscopy (NIRS), metabolomics, and data-driven decision support systems, in improving breeding efficiency, quality assessment, and supply chain management will be highlighted. By combining traditional knowledge with modern innovations, root and tuber crop systems can be transformed into sustainable value chains that reduce food loss, improve farmer livelihoods, and contribute to climate-resilient agriculture. This presentation will provide practical insights and case studies from ongoing research, offering pathways to greener and more inclusive food systems in line with global sustainability goals.